{"created":"2024-07-17T05:32:31.313680+00:00","id":2002281,"links":{},"metadata":{"_buckets":{"deposit":"326a5107-49b1-4336-869a-470a446b7f7d"},"_deposit":{"created_by":60,"id":"2002281","owner":"60","owners":[60],"pid":{"revision_id":0,"type":"depid","value":"2002281"},"status":"published"},"_oai":{"id":"oai:nihon-u.repo.nii.ac.jp:02002281","sets":["1712291647116:1712291773777:1712303026499:1721096539918"]},"author_link":[],"control_number":"2002281","item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-02-29","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"231","bibliographicPageStart":"223","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"研究紀要","bibliographic_titleLang":"ja"}]}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Peptide bonds are important chemical linkages constituting many natural products and pharmaceuticals. Although \nthe dehydrative condensation of the amino acids is the most straightforward approach to construct peptide bonds, the \ncommon methods require a stoichiometric amount of coupling reagents, which causes the problems associated with poor \natom economy and practical operation. In contrast, the catalytic direct dehydrative peptide bond formation is an ideal \napproache because water is the only byproduct. This article highlights our recent studies on diboronic acid anhydride \n(DBAA)-catalyzed dehydrative peptide bond formations. DBAA designed based on a recent mechanism has been identified as a powerful catalyst for dehydrative condensations of β-hydroxy-α-amino acids, affording the serine, threonine, or \nhydroxy valine-derived peptides in high to excellent yields with high functional group tolerance, minimum epimerization, \nand excellent chemoselectivity.  The synthetic utility of the catalysis was demonstrated by the concise synthesis of 2,5-diketopiperazines.","subitem_description_type":"Abstract"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15006/0002002281","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本大学文理学部自然科学研究所","subitem_publisher_language":"ja"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00184953","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0369-3562","subitem_source_identifier_type":"EISSN"}]},"item_10002_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"嶋田, 修之","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-07-25"}],"filename":"059_P223.pdf","filesize":[{"value":"795 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://nihon-u.repo.nii.ac.jp/record/2002281/files/059_P223.pdf"},"version_id":"c2faa7e2-4f79-4960-bda1-09fe728c4a54"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dehydrative condensation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"amide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diboronic acid anhydride","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"organoboron catalysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chemoselectivity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diketopiperazines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"natural product synthesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"新規脱水縮合触媒によるペプチド結合形成反応の開発と ジケトピペラジンの簡便合成への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規脱水縮合触媒によるペプチド結合形成反応の開発と ジケトピペラジンの簡便合成への応用","subitem_title_language":"ja"},{"subitem_title":"Development of Peptide Bond Formation Utilizing Novel Dehydrative Condensation Catalyst and  Its Application to the Concise Synthesis of Diketopiperazines","subitem_title_language":"en"}]},"item_type_id":"40002","owner":"60","path":["1721096539918"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-07-25"},"publish_date":"2024-07-25","publish_status":"0","recid":"2002281","relation_version_is_last":true,"title":["新規脱水縮合触媒によるペプチド結合形成反応の開発と ジケトピペラジンの簡便合成への応用"],"weko_creator_id":"60","weko_shared_id":-1},"updated":"2024-07-30T07:33:55.515778+00:00"}